Questions and answers (FAQ)
Here you can find answers to commonly asked questions, organized according to the following categories:General questions
How much information can I get as a donor?
From the beginning, voluntary donors are entitled to comprehensive information and answers to their questions: At registration or blood withdrawl for a tissue compatibility test or when there is a question about a blood stem cell donation, information is provided by doctors in the regional blood transfusion service. Before the harvesting of blood stem cells, information is provided by doctors at the harvesting center.
What is a familial transplantation?
In contrast to transplantation between unrelated individuals, in familial transplantation healthy blood stem cells are transferred between siblings. The chance of finding a compatible donor within the family is about 25%.
What financial consideration can I expect for my donation?
The donation of blood stem cells is voluntary and comes from a solidarity with sick fellow human beings. For ethical reasons, blood stem cell donation is as blood donation made without financial consideration.
However, the full amounts of laboratory, doctor and hospital costs are covered. In addition, direct out of pocket expenses and loss of salary is reimbursed in case the employer doesn't do so.
Why do I have to complete a donor questionnaire even though I already registered abroad?
The donation regulations of Switzerland apply.
Can I cancel if in a few years I don't want to donate anymore?
You can leave the register for blood stem cells at any time and without any given reason.
A phone call does it!
How long does my information stay in your databank?
You remain registered in our databank until you have reached age 60, thereafter your dossier is made inactive.
Is it true that the costs of the hospital stay, loss of income, as well as all direct out of pocket expenses are reimbursed by your foundation?
Yes, all direct costs/losses in connection with the blood stem cell donation will be reimbursed to you.
The costs of the hospital stay and all medical evaluations will be passed on from Swiss Blood Stem Cells the patient. Beyond that, there is no financial compensation for blood stem cell donation: similar to blood donation, for ethical reasons no one should receive financial compensation for blood stem cell donation.
Why should I donate? There are certainly enough people who are available.
The likelihood of finding a matching blood stem cell donor very much depends on the combination of the various HLA antigens (tissue markers).
The chances of this vary greatly, but are usually very small. Therefore, it's important that as many people worldwide as possible are willing to register as a blood stem cell donor.
I have read that donor and recipient always remain anonymous. This strict rule doesn't exist in every country. What happens with my data when the designated recipient of my stem cells lives in one of those countries?
In Switzerland, total anonymity between patient and donor is required by law. This means, regardless of where the patient is, you as the donor remain anonymous.
Will I be detained on my next trip to the USA because of the databank?
No, because your data is not communicated to either national or international authorities. The data is only used for searching for donors and always remains anonymous in communications. Only your HLA-typing (tissue markers), gender and birth date is saved, no other data about you.
Can I depend on my data being handled in a trustworthy fashion?
As with blood donation, the donor and recipient of blood stem cells may not know each other. This rule serves to protect the privacy of the donor and recipient. Therefore, the personal data of the donor remains anonymous, only a donor number is used in the registry of Swiss Blood Stem Cells as well as communications with the transplantation center.
What exactly happens with my data when I make myself available as a donor?
This data is made anonymous and saved in the register of Blood Stem Cells and is made available in an international databank for the search for a suitable donor.
Is there financial compensation for the donation of blood stem cells?
The donation of blood stem cells is made voluntarily and out of solidarity toward fellow human beings who are ill. Just as in blood donation, out of moral considerations no financial compensation is provided. However, all laboratory, doctor and hospital costs are covered. In addition, direct out of pocket expenses and loss of income are reimbursed should the donor's employer not do so.
to register / tissue typing
Who can register as a blood stem cell donor and become a potential donor?
Any healthy person who meets the criteria for donating blood, and is between the ages of 18 and 45 can register as a donor. But the actual donation can be made from age 18 until age 60.
What is tissue typing and how is it done?
In tissue typing, the HLA-antigens are determined through a blood or saliva sample. Some regional blood donation services conduct the first typing of HLA-A and HLA-B antigens themselves. All antigens relevant for a transplantation (HLA-A, HLA-B and HLA-DR) are ascertained at the National Reference Laboratory for Histocompatibility in Geneva.
Is entry into the register of Blood Stem Cells voluntary?
The entry into the register is voluntary. It happens after an individual indicates his or her intention to register, and after the results of the tissue typing are known and blood donation compatibility is confirmed (e.g., infection marker).
Will I be detained on my next trip to the USA because of the databank?
No, because your data is not communicated to either national or international authorities. The data is only used for searching for donors and always remains anonymous in communications. Only your HLA-typing (tissue markers), gender and birth date is saved, no other data about you.
Can I depend on my data being handled in a trustworthy fashion?
As with blood donation, the donor and recipient of blood stem cells may not know each other. This rule serves to protect the privacy of the donor and recipient. Therefore, the personal data of the donor remains anonymous, only a donor number is used in the registry of Swiss Blood Stem Cells as well as communications with the transplantation center.
What exactly happens with my data when I make myself available as a donor?
This data is made anonymous and saved in the register of Blood Stem Cells and is made available in an international databank for the search for a suitable donor.
How are my blood stem cells identified? How can it be determined if I'm eligible?
The blood stem cells themselves are not identified. The conformance of the tissue markers (HLA) between the donor and recipient is crucial to the success of a blood stem cells transplantation. Otherwise the body rejects the foreign blood stem cells or the blood stem cells reject the foreign body. Thus, with every registered blood stem cell donor, a tissue typing is done. This data is then- anonymously- entered into a worldwide databank and, when there is a request, is compared to a patient's tissue typing.
To donate blood stem cells
As a registered blood stem cell donor, until what age am I eligible to donate?
According to the regulations for donation and transplantation of hemopoietic stem cells from non-relative donors, transplantations of blood stem cells in Switzerland from non-relative donors are done in children and adults up to age 65. For patients between the ages of 65 and 89, there are special criteria.
What does tissue compatibility mean in regards to blood stem cell donation?
In the transplantation of organs, organ parts or cells, the overriding goal is to have a complete match of the HLA system, depending on the type of material being transplanted. Before any transplantation of blood stem cells, the blood of the donor and patient is evaluated for reciprocal tissue compatibility.
What happens in bone marrow harvest?
Bone marrow is obtained from the iliac crest through multiple punctures with a syringe. The harvest is done under full anesthesia and performed by specialists in one of the harvest centers in Basel, Geneva or Zurich. Usually the donor can already leave the hospital the day after the procedure.
What are the side effects of bone marrow donation?
For a few days after the procedure, a donor can expect to have some pain at the puncture sites as well as fatigue due to the anesthesia and blood loss. Otherwise there are no other health impairments or permanent side effects to be expected. The bone marrow completely regenerates within a few weeks.
What is a familial transplantation?
In contrast to transplantation between unrelated individuals, in familial transplantation healthy blood stem cells are transferred between siblings. The chance of finding a compatible donor within the family is about 25%.
What happens in the collection of peripheral blood stem cells?
In the collection of peripheral blood stem cells, blood flows through a venous catheter to a cell separator. This separates the blood stem cells from the blood and collects them. Then the blood flows through a second venous catheter back to the donor. This type of donation takes 3 to 6 hours and is done outpatient at one of the harvest centers.
If there is a low yield of blood stem cells on the first day of collection, another collection can be done on the following day. In rare cases a third blood apheresis is required.
After registration/tissue typing request, how does donation occur?
The request for donation comes through the regional blood transfusion service. After a face to face meeting with the doctor and consent of the donor, blood samples are taken to determine the donor's blood donation compatibility and repeated and more in-depth typing and tissue compatibility tests are done.
Harvesting of blood stem cells per se, is only done when donor suitability has been confirmed by a doctor and tissue compatibility testing shows a match with the patient's blood.
What happens with my blood stem cells after my donation?
Blood stem cells have a very short lifespan and must be brought to the transplantation center and transplanted as quickly as possible. This means that the harvesting and transplantation must be coordinated so that the harvested blood stem cells can be transplanted, at the latest, within 48 to 72 hours - even when the transport distance is over thousands of kilometers.
Why should I donate? There are certainly enough people who are available.
The likelihood of finding a matching blood stem cell donor very much depends on the combination of the various HLA antigens (tissue markers).
The chances of this vary greatly, but are usually very small. Therefore, it's important that as many people worldwide as possible are willing to register as a blood stem cell donor.
Should I expect side effects (temporary and long term consequences) with a peripheral or bone marrow donation.
Today's harvesting techniques involve very safe and established methods to ensure that a donation is usually well tolerated, except for a few unpleasant, short term, side effects. Very rarely, serious side effects may occur, but through in depth questioning and medical examination prior to the donation, your state of health is evaluated. The donation will only take place if there is no increased risk to your health.
A rare, but possible, risk connected to the administration of growth factors (G-CSF) is thrombosis. Negative side effects have also been observed with donors that have a predisposition to inflammatory diseases. Based on the available data of healthy donors that have received G-CSF, no relevant long-term complications have been observed. Only in very few cases, rupture of the spleen has occurred. The data from different donor registries shows that administration of G-CSF is safe. Compared to the non-donating population, there is no increase in tumor-related diseases. To contain the risk of side effects due to growth factors, in Switzerland the same donor can only donate peripheral blood stem cells once.
Because studies on the long term side effects of growth factors are not yet conclusive, the donor's blood is periodically checked after donation. So far the results have not shown any negative effects compared to the normal population.
Are side effects of Neupogen common?
With a donation of peripheral blood stem cells through the administration of growth factors, temporary flu-like symptoms, such as fever, headache, and joint pain, as well as fatigue, may occur. Here as well, the intensity of those symptoms may vary from individual to individual.
Is the donation of bone marrow painful?
After the harvesting, you will have a possibly bothersome hematoma (bruise) in the iliac crest. You will possibly feel fatigued for a few days and you could have dull pain at the puncture site. This pain though only lasts a few days and can be alleviated with pain medication. However, the extent of side effects varies from individual to individual.
Can I depend on my data being handled in a trustworthy fashion?
As with blood donation, the donor and recipient of blood stem cells may not know each other. This rule serves to protect the privacy of the donor and recipient. Therefore, the personal data of the donor remains anonymous, only a donor number is used in the registry of Swiss Blood Stem Cells as well as communications with the transplantation center.
Why doesn't a normal blood donation suffice?
For a blood stem cell transplantation a larger number of healthy, immature blood stem cells are needed. These can usually only be found in bone marrow. In blood and thus in a normal blood donation, there is almost exclusively mature blood cells.
What side effects can occur in a donation of peripheral blood stem cells?
About 5 days before the scheduled harvesting, the donor is given injections of growth factors to increase the number of blood stem cells. This can cause flu-like side effects such as headache and joint pain. With the harvesting itself, bleeding and/or pain can occur at the puncture site. Because studies on the long term effects of growth factors are not yet conclusive, the donor's blood is periodically checked after the procedure.
Will personal questions be answered before the donation?
Voluntary donors are from the beginning entitled to comprehensive information and answers to their individual questions.
At registration or blood withdrawl for tissue compatibility tests or regarding question about blood stem cell donation, information is provided by doctors at the regional blood transfusion service. Prior to the harvesting of <dfn title="hematopoietic stem cells">blood stem cells</dfn>, the information is provided by doctors at the harvest center.
Is there financial compensation for the donation of blood stem cells?
The donation of blood stem cells is made voluntarily and out of solidarity toward fellow human beings who are ill. Just as in blood donation, out of moral considerations no financial compensation is provided. However, all laboratory, doctor and hospital costs are covered. In addition, direct out of pocket expenses and loss of income are reimbursed should the donor's employer not do so.
Medical questions
What happens in bone marrow harvest?
Bone marrow is obtained from the iliac crest through multiple punctures with a syringe. The harvest is done under full anesthesia and performed by specialists in one of the harvest centers in Basel, Geneva or Zurich. Usually the donor can already leave the hospital the day after the procedure.
What are the side effects of bone marrow donation?
For a few days after the procedure, a donor can expect to have some pain at the puncture sites as well as fatigue due to the anesthesia and blood loss. Otherwise there are no other health impairments or permanent side effects to be expected. The bone marrow completely regenerates within a few weeks.
What does the mobilization of blood stem cells mean?
Blood stem cells can be mobilized out of the bone marrow into the circulating blood, e.g., with blood stem cell donation through the administration of growth factors (G-CSF).
What happens in the collection of peripheral blood stem cells?
In the collection of peripheral blood stem cells, blood flows through a venous catheter to a cell separator. This separates the blood stem cells from the blood and collects them. Then the blood flows through a second venous catheter back to the donor. This type of donation takes 3 to 6 hours and is done outpatient at one of the harvest centers.
If there is a low yield of blood stem cells on the first day of collection, another collection can be done on the following day. In rare cases a third blood apheresis is required.
Should I expect side effects (temporary and long term consequences) with a peripheral or bone marrow donation.
Today's harvesting techniques involve very safe and established methods to ensure that a donation is usually well tolerated, except for a few unpleasant, short term, side effects. Very rarely, serious side effects may occur, but through in depth questioning and medical examination prior to the donation, your state of health is evaluated. The donation will only take place if there is no increased risk to your health.
A rare, but possible, risk connected to the administration of growth factors (G-CSF) is thrombosis. Negative side effects have also been observed with donors that have a predisposition to inflammatory diseases. Based on the available data of healthy donors that have received G-CSF, no relevant long-term complications have been observed. Only in very few cases, rupture of the spleen has occurred. The data from different donor registries shows that administration of G-CSF is safe. Compared to the non-donating population, there is no increase in tumor-related diseases. To contain the risk of side effects due to growth factors, in Switzerland the same donor can only donate peripheral blood stem cells once.
Because studies on the long term side effects of growth factors are not yet conclusive, the donor's blood is periodically checked after donation. So far the results have not shown any negative effects compared to the normal population.
Are side effects of Neupogen common?
With a donation of peripheral blood stem cells through the administration of growth factors, temporary flu-like symptoms, such as fever, headache, and joint pain, as well as fatigue, may occur. Here as well, the intensity of those symptoms may vary from individual to individual.
To registration events
My brother has leukemia. Can I, as a private individual, organize a registration event?
We are pleased when a private engagement involves the registration of voluntary non-relative donors. Please note that with such an event, the registered individuals should be available for all patients.
We would like to hold our anniversary celebration as a charity event to benefit those that suffer from leukemia. What are the options for this?
We think your idea is great. Many ill people who suffer from leukemia need a blood stem cell donor. Why not organize your annual celebration as a registration event and invite the staff and their families. We would be happy to help!
What financial consideration can I expect for my donation?
The donation of blood stem cells is voluntary and comes from a solidarity with sick fellow human beings. For ethical reasons, blood stem cell donation is as blood donation made without financial consideration.
However, the full amounts of laboratory, doctor and hospital costs are covered. In addition, direct out of pocket expenses and loss of salary is reimbursed in case the employer doesn't do so.


